The Effect of UDMH Injection on Complex Avoidance Behavior in the Java Monkey
Report Number: AMRL TDR 63-39
Author(s): Reynolds, Herbert H., Rohles, Frederick H. , Carter, Vernon L., Brunson, Henry W., Prime, James R.
Corporate Author(s): Aerospace Medical Research Laboratory
Laboratory: Aerospace Medical Research Laboratory
Date of Publication: 1963-05
Pages: 29
Contract: Laboratory Research - No Contract
DoD Project: 6302
DoD Task: 630202
Identifier: AD0410933
Abstract:
Four java monkeys were injected with 30 mg/kg of 1,1- dimethylhydrazine (UDMH) and their performance on a four-component operant schedule was compared with their performance under control conditions. In every instance where a performance decrement occurred (9 out of a possible 32), there was also associated clinical illness in the form of hyperactivity, nausea, vomiting, or lethargy. One subject showed no impairment following the two UDMH injections, while another subject exhibited an impairment on all four tasks during the second replication; this suggests the range of individual reactivity to UDMH exposure, and that repeated severe exposure may cause serious decrement of performance. From these data, one may expect clinical signs of illness after 2 to 3 hours, a performance decrement or change after 3 to 3-1/2 hours, and recovery to pre-exposure level of functioning between six and nine hours.
Provenance: RAF Centre of Aviation Medicine
Author(s): Reynolds, Herbert H., Rohles, Frederick H. , Carter, Vernon L., Brunson, Henry W., Prime, James R.
Corporate Author(s): Aerospace Medical Research Laboratory
Laboratory: Aerospace Medical Research Laboratory
Date of Publication: 1963-05
Pages: 29
Contract: Laboratory Research - No Contract
DoD Project: 6302
DoD Task: 630202
Identifier: AD0410933
Abstract:
Four java monkeys were injected with 30 mg/kg of 1,1- dimethylhydrazine (UDMH) and their performance on a four-component operant schedule was compared with their performance under control conditions. In every instance where a performance decrement occurred (9 out of a possible 32), there was also associated clinical illness in the form of hyperactivity, nausea, vomiting, or lethargy. One subject showed no impairment following the two UDMH injections, while another subject exhibited an impairment on all four tasks during the second replication; this suggests the range of individual reactivity to UDMH exposure, and that repeated severe exposure may cause serious decrement of performance. From these data, one may expect clinical signs of illness after 2 to 3 hours, a performance decrement or change after 3 to 3-1/2 hours, and recovery to pre-exposure level of functioning between six and nine hours.
Provenance: RAF Centre of Aviation Medicine