Effects of Decaborane on Brain Activity
Report Number: AMRL TDR 63-41
Author(s): Delgado, Jose M.
Corporate Author(s): Yale University
Laboratory: Biomedical Laboratory
Date of Publication: 1963-05
Pages: 22
Contract: AF 33(657)-9021
DoD Project: 6302
DoD Task: 630202
Identifier: AD0411769
Abstract:
The effects on intraperitoneal injection of decaborane have been investigated in monkeys with electrodes permanently implanted in the brain. One single injection of 5 mg/kg produced a marked behavioral depression, with only moderate electroencephalographic modifications, followed by death in 18 hours. Four daily doses of 3 mg/kg produced depression, somnolence, twitching in both arms, accompanied by bursts of high-voltage activity, localized in the internal capsule. Death occurred 3 days later. Daily doses of 1 mg/kg up to a total of 14 mg/kg pro produced depression, muscular twitching, anorexia, and a typical electroencephalographic pattern, but the animals recovered completely. Depression may be related to reticular system involvement. Motor symptomatology could depend on disturbances of heavily myelinated motor axons which may have a special affinity for the liposoluble decaborane. Hypothalamic involvement was questionable, but neighboring structures, especially the internal capsule showed electrical disturbances.
Provenance: RAF Centre of Aviation Medicine
Author(s): Delgado, Jose M.
Corporate Author(s): Yale University
Laboratory: Biomedical Laboratory
Date of Publication: 1963-05
Pages: 22
Contract: AF 33(657)-9021
DoD Project: 6302
DoD Task: 630202
Identifier: AD0411769
Abstract:
The effects on intraperitoneal injection of decaborane have been investigated in monkeys with electrodes permanently implanted in the brain. One single injection of 5 mg/kg produced a marked behavioral depression, with only moderate electroencephalographic modifications, followed by death in 18 hours. Four daily doses of 3 mg/kg produced depression, somnolence, twitching in both arms, accompanied by bursts of high-voltage activity, localized in the internal capsule. Death occurred 3 days later. Daily doses of 1 mg/kg up to a total of 14 mg/kg pro produced depression, muscular twitching, anorexia, and a typical electroencephalographic pattern, but the animals recovered completely. Depression may be related to reticular system involvement. Motor symptomatology could depend on disturbances of heavily myelinated motor axons which may have a special affinity for the liposoluble decaborane. Hypothalamic involvement was questionable, but neighboring structures, especially the internal capsule showed electrical disturbances.
Provenance: RAF Centre of Aviation Medicine