Determination of Hydrazine and 1-Methylhydrazine in Blood Serum

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Report Number: AMRL TDR 64-24
Author(s): Reynolds, Barbara A., Thomas, Anthony A.
Corporate Author(s): Biomedical Laboratory
Laboratory: Biomedical Laboratory
Date of Publication: 1964-04
Pages: 16
Contract: Laboratory Research - No Contract
DoD Project: 6302
DoD Task: 630202
Identifier: AD0441231

Abstract:
A simple procedure is described for measuring microgram amounts of hydrazine in the blood serum of rats. The procedure, with a minor modification, can be used for measuring microgram amounts of 1-methylhydrazine. The report presents calibration ranges of 0.5-5.0 micrograms/ml and 0.5-10.0 micrograms/ml of hydrazine and 1-methylhydrazine, respectively. Data are presented on the dose-blood-level relationship of hydrazine and 1-methylhydrazine in rats following intraperitoneal injection. Minimum detectable dose levels were 0.6 mg/kg and 3.0 mg/kg of hydrazine and 1-methylhydrazine, respectively.

Provenance: RAF Centre of Aviation Medicine

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