Fate of UDMH and MMH in Rats
Report Number: AMRL TR 64-111
Author(s): Reed, D. J., Dost, F. N., Wang, C. H.
Corporate Author(s): Oregon State University
Laboratory: Biomedical Laboratory
Date of Publication: 1964-12
Pages: 28
Contract: AF 33(657)-11757
DoD Project: 6302
DoD Task: 630202
Identifier: AD0610569
Abstract:
Many of the applications of hydrazines, especially as rocket propellants and in medicine, give them considerable toxicological importance. The respiratory and urinary excretion by rats of unsymmetrical dimethylhydrazine (UDMH) and monomethylhydrazine (MMH) and their metabolites has been studied by means of radiotracer techniques. At a very low dose, almost 30% of the C14 from i.p. administered UDMH-C14 appeared as respiratory C14O2 in 10 hours. At a convulsive dose, the conversion of UDMH-C14 to C14O2 amounted to slightly greater than 13% at the end of 20 hours. At all doses studied radioactivity appeared in the urine to the extent of at least 50% of the administered UDMH-C14, at the end of two days after administration. Rats administered MMH-C14 by i. p. injection at 20% of a median lethal dose respired approximately 45% of the administered radioactivity in 24 hours. The respired radioactivity consisted of at least two components; 20-25% was C14O2, and the remainder was a C14 labeled volatile compound tentatively identified as methane-C14. At the sub-convulsive doses, 40% of the administered radioactivity in MMH-C14 was excreted in urine. At a toxic dose the percentage of urinary excretion of C14 decreased, but net molar excretion increased slightly. The design of an animal radiorespirometric system capable of continuously monitoring C14 in respiratory gases from separate animals is described.
Provenance: RAF Centre of Aviation Medicine
Author(s): Reed, D. J., Dost, F. N., Wang, C. H.
Corporate Author(s): Oregon State University
Laboratory: Biomedical Laboratory
Date of Publication: 1964-12
Pages: 28
Contract: AF 33(657)-11757
DoD Project: 6302
DoD Task: 630202
Identifier: AD0610569
Abstract:
Many of the applications of hydrazines, especially as rocket propellants and in medicine, give them considerable toxicological importance. The respiratory and urinary excretion by rats of unsymmetrical dimethylhydrazine (UDMH) and monomethylhydrazine (MMH) and their metabolites has been studied by means of radiotracer techniques. At a very low dose, almost 30% of the C14 from i.p. administered UDMH-C14 appeared as respiratory C14O2 in 10 hours. At a convulsive dose, the conversion of UDMH-C14 to C14O2 amounted to slightly greater than 13% at the end of 20 hours. At all doses studied radioactivity appeared in the urine to the extent of at least 50% of the administered UDMH-C14, at the end of two days after administration. Rats administered MMH-C14 by i. p. injection at 20% of a median lethal dose respired approximately 45% of the administered radioactivity in 24 hours. The respired radioactivity consisted of at least two components; 20-25% was C14O2, and the remainder was a C14 labeled volatile compound tentatively identified as methane-C14. At the sub-convulsive doses, 40% of the administered radioactivity in MMH-C14 was excreted in urine. At a toxic dose the percentage of urinary excretion of C14 decreased, but net molar excretion increased slightly. The design of an animal radiorespirometric system capable of continuously monitoring C14 in respiratory gases from separate animals is described.
Provenance: RAF Centre of Aviation Medicine