Antiarrhythmic Activity of Antazoline and its Application to the Control of Hypothermic Ventricular Fibrillation

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Report Number: AMRL TR 65-201
Author(s): Angelakos, E. T.
Corporate Author(s): Boston University School of Medicine
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1965-12
Pages: 36
Contract: AF 33(657)-10755
DoD Project: 7164
DoD Task: 716409
Identifier: AD0629548

The chemistry and general pharmacology of antazoline and experimental studies employing it are reviewed to determine the antiarrhythmic activity and the protective effect of antazoline against hypothermic ventricular fibrillation. In hypothermic ventricular fibrillation and in clinically observed heart disorders, the antiarrhythmic activity of antazoline was often superior to other pharmacological agents, including quinidine. The incidence of side effects, notably nausea or vomiting, was found to be related to the dosage. Since the basis of the antiarrhythmic activity of antazoline is essentially unknown, further studies in this direction are warranted to provide for systematic development of more effective compounds.

Provenance: RAF Centre of Aviation Medicine

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