Further Study of the Mechanism of Acute Toxic Effects of 1,1-Dimethylhydrazine, Methylhydrazine, and 1,2-Dimethylhydrazine

Download this report (PDF, 0.6 MB, 24 pages)
Report Number: AMRL TR 65-48
Author(s): Weir, Francis W., Myers, Frederick H., Arbuckle, Robert H., Nemenzo, Jesus H.
Corporate Author(s): Hine Laboratories, Inc.
Laboratory: Biomedical Laboratory
Date of Publication: 1965-05
Pages: 24
Contract: AF 33(657)-11756
DoD Project: 6302
DoD Task: 630202
Identifier: AD0617692

Abstract:
Investigations were designed to explore mechanisms of toxic action of SDMH, UDMH, and MMH. SDMH is more toxic when administered in strongly acid (less than pH 1.0) or alkaline (pH 11.0) solutions than when administered in buffered solutions. The acute toxicity to mice of unbuffered SDMH- dihydrochloride is not different from hydrochloric acid. The tenfold difference between the acute toxicity of SDMH at 24 and 168 hours for mice is not seen in rats or dogs. The degree and time course of liver damage in mice is such that it is probably responsible for the delayed deaths seen in this species. The previously reported selective protective action of various substituted benzaldehydes against UDMH and MMH in mice was not observed in rats. Prophylactic treatment with amino-oxyacetic acid provided protection to rats against the lethal effects of UDMH, but not against the effects of MMH. The mechanism and site of action of UDMH (1,1-dimethylhydrazine), MMH (methylhydrazine), and SDMH (1,2-dimethylhydrazine) were investigated. Discrete localized lesions produced in specific areas of the otherwise intact brain stem by suction or electrolytic destruction modify or abolish UDMH-induced convulsions in dogs. The area from which these convulsions arise has been localized to a ventral mid-collicular site.

Provenance: RAF Centre of Aviation Medicine

Other options for obtaining this report:

Via the Defense Technical Information Center (DTIC):
A record for this report, and possibly a pdf download of the report, exists at DTIC

Via National Technical Report Library:
This report may be available for download from NTRL. Use the Title from this record to locate the item in DTIC Online

Indications of Public Availability
No digital image of an index entry indicating public availability is currently available
There has been no verification of an indication of public availability from an inside cover statement



Export