1, 1-Dimethylhydrazine Effects on Central Excitatory and inhibitory Mechanisms in Cats
Report Number: AMRL TR 65-142
Author(s): Fairchild, M. D., Sterman, M. B.
Corporate Author(s): University of California, Los Angeles
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1965-08
Pages: 39
Contract: AF 41(609)-2329
DoD Project: 6302
DoD Task: 630202
Identifier: AD0623786
Abstract:
Experiments, using cats with chronically implanted brain electrodes, were performed to explore the influence of subconvulsive doses of 1, 1- dimethylhydrazine (UDMH) on certain excitatory and inhibitory mechanisms in the central nervous system (CNS). The cats were stimulated electrically in the midbrain reticular activating system, the basal forebrain inhibitory area, and both areas simultaneously while the animal was tested for performance in a positively reinforced experimental situation. UDMH was compared with amphetamine, chlorpromazine and phenobarbital both in the presence and absence of CNS stimulation. UDMH acted in a manner similar to chlorpromazine in subconvulsive doses in these tests. The most interesting and consistent effect of UDMH was to abort performance when the basal forebrain inhibitory area was stimulated. The animals resumed performance when the stimulus was terminated. UDMH has detectable CNS effects at doses well below convulsive levels.
Provenance: RAF Centre of Aviation Medicine
Author(s): Fairchild, M. D., Sterman, M. B.
Corporate Author(s): University of California, Los Angeles
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1965-08
Pages: 39
Contract: AF 41(609)-2329
DoD Project: 6302
DoD Task: 630202
Identifier: AD0623786
Abstract:
Experiments, using cats with chronically implanted brain electrodes, were performed to explore the influence of subconvulsive doses of 1, 1- dimethylhydrazine (UDMH) on certain excitatory and inhibitory mechanisms in the central nervous system (CNS). The cats were stimulated electrically in the midbrain reticular activating system, the basal forebrain inhibitory area, and both areas simultaneously while the animal was tested for performance in a positively reinforced experimental situation. UDMH was compared with amphetamine, chlorpromazine and phenobarbital both in the presence and absence of CNS stimulation. UDMH acted in a manner similar to chlorpromazine in subconvulsive doses in these tests. The most interesting and consistent effect of UDMH was to abort performance when the basal forebrain inhibitory area was stimulated. The animals resumed performance when the stimulus was terminated. UDMH has detectable CNS effects at doses well below convulsive levels.
Provenance: RAF Centre of Aviation Medicine