Models of Neuroelectric Interactions
Report Number: AMRL TR 67-132
Author(s): Lewis, Edwin R.
Corporate Author(s): Librascope Group, General Precision Systems, Inc.
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1967-12
Pages: 148
Contract: AF 33(615)-2464
DoD Project: 7233 - Biological Information Handling Systems and Their Functional Analogs
DoD Task: 723305 - Theory of Information Handling
Identifier: AD0669574
Abstract:
The Hodgkin-Huxley descriptions of electrically excitable conductances are combined with Eccles descriptions of synaptic conductances to provide the basis of an electronic analog of nerve cell membrane. A neural simulation facility is constructed, comprising ten pairs of these analogs with associated input and output equipment. A detailed description of the simulation facility is presented, including design philosophy, circuit, system and mechanical details. The simulation facility is used to model spatially distributed neuroelectric phenomena. Significant results include resetting of potentials in integrative regions by spikes generated at a remote site, stable spike synchrony in independently driven, mutually inhibiting distributed neural models, burst formation in mutually exciting neural models, and various nonuniformities of wave shape and velocity in conduction along a distributed axon. In addition, the facility is used in a simulation study of the lobster cardiac ganglion. As results of this study, mechanisms are proposed for ganglion operation and specific neuronal connectivities are predicted.
Provenance: RAF Centre of Aviation Medicine
Author(s): Lewis, Edwin R.
Corporate Author(s): Librascope Group, General Precision Systems, Inc.
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1967-12
Pages: 148
Contract: AF 33(615)-2464
DoD Project: 7233 - Biological Information Handling Systems and Their Functional Analogs
DoD Task: 723305 - Theory of Information Handling
Identifier: AD0669574
Abstract:
The Hodgkin-Huxley descriptions of electrically excitable conductances are combined with Eccles descriptions of synaptic conductances to provide the basis of an electronic analog of nerve cell membrane. A neural simulation facility is constructed, comprising ten pairs of these analogs with associated input and output equipment. A detailed description of the simulation facility is presented, including design philosophy, circuit, system and mechanical details. The simulation facility is used to model spatially distributed neuroelectric phenomena. Significant results include resetting of potentials in integrative regions by spikes generated at a remote site, stable spike synchrony in independently driven, mutually inhibiting distributed neural models, burst formation in mutually exciting neural models, and various nonuniformities of wave shape and velocity in conduction along a distributed axon. In addition, the facility is used in a simulation study of the lobster cardiac ganglion. As results of this study, mechanisms are proposed for ganglion operation and specific neuronal connectivities are predicted.
Provenance: RAF Centre of Aviation Medicine