Cutaneous Toxicity Evaluation of Air Force Development Materials - VI

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Report Number: AMRL TDR 64-13
Author(s): Shelanski, Morris V.
Corporate Author(s): Industrial Biology Research and Testing Laboratories, Inc.
Laboratory: Biomedical Laboratory
Date of Publication: 1964-02
Pages: 15
Contract: AF 33(657)-8900
DoD Project: 6302
DoD Task: 630201
Identifier: AD0435776

Ten Air Force development materials were studied via the prophetic patch test method on laboratory animals to determine the primary irritant effect, gross sensitization index, and gross percutaneous toxicity of these materials. The patch test studies with rabbits indicated that three of the materials showed very mild primary irritant action. None of the materials produced any sensitization or gross systemic poisoning. Dermal reactions on rabbits were so mild that testing on humans was not precluded. The materials were, therefore, tested on human volunteers by the Shelanski repeated insult patch test. Results of this test indicated that all of the materials were safe to use on contact with human skin.

Provenance: RAF Centre of Aviation Medicine

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