Toxicity Studies of Coolanol 15
Report Number: AMRL TR 65-213
Author(s): Zielger, Ralph F., Robinson, Farrel R., Harper, David T.
Corporate Author(s): Aerospace Medical Research Laboratories
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1965-12
Pages: 18
Contract: Laboratory Research - No Contract
DoD Project: 6302
DoD Task: 630201
Identifier: AD0637453
Abstract:
Coolanol 15* (formerly designated MCS 198), a synthetic heat transfer fluid, is currently being used in the heat transfer systems of manned spacecraft. The current studies were undertaken to confirm or refute previously reported effects on the central nervous system and to acquire additional information on the toxicity of this compound. The effects of single intraperitoneal injections in mice and rats, repeated subcutaneous injections in rabbits, and the repeated cutaneous application on the unabraded skin of rabbits, monkeys, and dogs were investigated. Parenteral injection revealed that Coolanol 15 is relatively nontoxic. The LD50 for mice was found to be greater than 20.0 gm (22,2 ml) per kg at 24 hours and 5.9 gm (6.6ml) per kg at 7 and 14 days. Repeated subcutaneous injections in rabbits resulted primarily in localized reactions at injection sites. The only effects which could be directly attributed to the cutaneous application of 3.6 gm (4.0 ml) per kg per day for 20 days involved the skin. Drying and encrustation and/or desquamation of the superficial layers of the skin were the principal lesions observed clinically while microscopic examination revealed varying degrees of hyperkeratosis and cellular infiltration. These studies failed to confirm the previously reported lesions in the central nervous system attributed to Coolanol 15.
Provenance: RAF Centre of Aviation Medicine
Author(s): Zielger, Ralph F., Robinson, Farrel R., Harper, David T.
Corporate Author(s): Aerospace Medical Research Laboratories
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1965-12
Pages: 18
Contract: Laboratory Research - No Contract
DoD Project: 6302
DoD Task: 630201
Identifier: AD0637453
Abstract:
Coolanol 15* (formerly designated MCS 198), a synthetic heat transfer fluid, is currently being used in the heat transfer systems of manned spacecraft. The current studies were undertaken to confirm or refute previously reported effects on the central nervous system and to acquire additional information on the toxicity of this compound. The effects of single intraperitoneal injections in mice and rats, repeated subcutaneous injections in rabbits, and the repeated cutaneous application on the unabraded skin of rabbits, monkeys, and dogs were investigated. Parenteral injection revealed that Coolanol 15 is relatively nontoxic. The LD50 for mice was found to be greater than 20.0 gm (22,2 ml) per kg at 24 hours and 5.9 gm (6.6ml) per kg at 7 and 14 days. Repeated subcutaneous injections in rabbits resulted primarily in localized reactions at injection sites. The only effects which could be directly attributed to the cutaneous application of 3.6 gm (4.0 ml) per kg per day for 20 days involved the skin. Drying and encrustation and/or desquamation of the superficial layers of the skin were the principal lesions observed clinically while microscopic examination revealed varying degrees of hyperkeratosis and cellular infiltration. These studies failed to confirm the previously reported lesions in the central nervous system attributed to Coolanol 15.
Provenance: RAF Centre of Aviation Medicine