Metabolism and Pharmacology of Inorganic and Fluorine Containing Compounds
Report Number: AMRL TR 67-224
Author(s): Dost, Frank N., Reed, Donald J., Finch, Arthur, Wang, Chih H.
Corporate Author(s): Oregon State University
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1968-08
Pages: 102
Contract: AF 33(615)-1799
DoD Project: 6302
DoD Task: 630202
Identifier: AD0681161
Abstract:
Studies have been made of the toxicology and chemistry of nitrogen trifluoride, tetrafluorohydrazine, chlorine trifluoride, bromine pentafluoride, and oxygen difluoride. Lethality of each agent by inhalation has been determined, as well as estimates of lethality after intraperitoneal administration. Experimental evidence suggests that the lethal effect of interhalogens is by corrosive local destruction of pulmonary surfaces, resulting in failure of gas exchange. Oxygen difluoride is thought to pass intact into the pulmonary cells where it reacts with biochemical reducing systems to ultimately cause cell death and structural failure. The nitrogen fluorides both cause intrinsically lethal levels of methemoglobin formation, but other pharmacologic activity by these compounds or their derivatives may also contribute to their toxic activity.
Provenance: RAF Centre of Aviation Medicine
Author(s): Dost, Frank N., Reed, Donald J., Finch, Arthur, Wang, Chih H.
Corporate Author(s): Oregon State University
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1968-08
Pages: 102
Contract: AF 33(615)-1799
DoD Project: 6302
DoD Task: 630202
Identifier: AD0681161
Abstract:
Studies have been made of the toxicology and chemistry of nitrogen trifluoride, tetrafluorohydrazine, chlorine trifluoride, bromine pentafluoride, and oxygen difluoride. Lethality of each agent by inhalation has been determined, as well as estimates of lethality after intraperitoneal administration. Experimental evidence suggests that the lethal effect of interhalogens is by corrosive local destruction of pulmonary surfaces, resulting in failure of gas exchange. Oxygen difluoride is thought to pass intact into the pulmonary cells where it reacts with biochemical reducing systems to ultimately cause cell death and structural failure. The nitrogen fluorides both cause intrinsically lethal levels of methemoglobin formation, but other pharmacologic activity by these compounds or their derivatives may also contribute to their toxic activity.
Provenance: RAF Centre of Aviation Medicine