Distribution and Excretion of 14C-Monomethylhydrazine

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Report Number: AMRL TR 67-175
Author(s): Pinkerton, Mildred K., Hagan, Edgar A., Back, Kenneth C.
Corporate Author(s): Aerospace Medical Research Laboratories
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1967-11
Pages: 24
Contract: Laboratory Research - No Contract
DoD Project: 6302
DoD Task: 630202
Identifier: AD0666662

A total of 20 mice, 20 rats, 17 dogs, and 16 monkeys received intraperitoneal injections of 14C-monomethylhydrazine (MMH) at doses of 22 mg/kg (mice), 15 mg/kg (rats), and 10 mg/kg (monkeys and dogs). At 2, 4, 8, and 24 hours after exposure, representative samples of approximately 20 tissues from each animal were processed for 14C assay using liquid scintillation counting techniques. Both blood and urine samples were simultaneously analyzed by a chemical colorimetric method for unchanged MMH, and the results were correlated with total 14C content. Results of the 14C assays indicated that the mouse, rat, and monkey excreted twice as much as the dog in the first 2 hours, and that all 4 species excreted 25-40% of the total dose by 24 hours after injection. Approximately 50% of the total 14C excretion, at all experimental times, was apparently unchanged MMH as implied by the colorimetric results. Tissue distribution of 14C showed the highest concentrations in liver, kidney, bladder, pancreas, and blood serum. Both clinically and pathologically, the dog was apparently much more susceptible than the other species tested to the toxic effects of MMH and to severe kidney damage.

Provenance: RAF Centre of Aviation Medicine

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